By Risto J. Rintala, Mikko Pakarinen, Tomas Wester
This ebook offers readers with a succinct yet complete evaluate of present techniques in terms of intestinal failure, together with its therapy, with a selected specialize in fresh developments. the hole chapters deal with easy points of intestinal failure, together with etiology, medical pathophysiology, body structure of intestinal version, and intestinal microbiota. The issues of intestinal failure, akin to bacterial overgrowth and intestinal failure-associated liver ailment, are then mentioned. a chain of chapters in particular deal with very important concepts within the dietary, pharmacological, and surgical procedure of intestinal failure in addition to the concept that of intestinal rehabilitation. eventually, major rising advancements are thought of: regenerative medication and distraction enterogenesis. The authors are across the world well-known specialists from Europe and North the US who're preferably put to explain present wisdom and growth within the field.
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Additional resources for Current Concepts of Intestinal Failure
1999;23(5 Suppl):S117–20. Yang H, Teitelbaum DH. Novel agents in the treatment of intestinal failure: humoral factors. Gastroenterology. 2006;130(2 Suppl 1):S117–21. Sigalet DL, Martin GR, Butzner JD, Buret A, Meddings JB. A pilot study of the use of epidermal growth factor in pediatric short bowel syndrome. J Pediatr Surg. 2005;40:763–8. Jeppesen PB, Hartmann B, Thulesen J, Graff J, Lohmann J, Hansen BS, Tofteng F, Poulsen SS, Madsen JL, Holst JJ, Mortensen PB. Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon.
Musashi1, an RNAbinding protein, was originally thought to be a neural stem cell marker. However, subsequent studies demonstrated that Musashi1 was also present on intestinal and colonic stem cells . Utilizing this marker, the isolation of an unpure culture of intestinal stem cells from the jejunum was achieved. 2 Short Bowel Syndrome: Intestinal Adaptation Fig. 2 Model of epithelial regeneration in the small intestine 33 Differentiated enterocytes Goblet cell Enteroendocrine cell Transit amplifying compartment Position +4 stem cells Crypt base Paneth cells However, additional markers were clearly needed to purify this culture.
Nutr Hosp. 1999;14:81–90. 58. Fadrique B, Lopez JM, Bermudez R. Growth hormone plus high protein diet promotes adaptation after massive small bowel resection in aged rats. Exp Gerontol. 2001;36:1727–37. 59. Wilmore DW, Lacey JM, Soultanakis RP, Bosch RL, Byrne TA. Factors predicting a successful outcome after pharmacologic bowel compensation. Ann Surg. 1997;226:288–92. 60. Matarese LE, Seidner DL, Steiger E. Growth hormone, glutamine, and modified diet for intestinal adaptation. J Am Diet Assoc.