By Henry R. Black, Black
Compiling descriptions, effects, and analyses from 24 whole or soon-to-be-complete influential medical trials learning the efficacy of pharmacological remedy in high blood pressure, this precise reference examines remedy for high blood pressure from a number of views, together with trials backed by way of either foreign governments and pharmaceutical companies. prepared to facilitate handy comparability and review of effects for healing judgements, scientific Trials in high blood pressure ·identifies goals, inclusion/exclusion standards, baseline features of matters, and drug regimens ·spotlights trials that demonstrated the effectiveness of leap forward remedies equivalent to treating younger hypertensives with diastolic blood strain elevations ·reviews various drug studies-including center assault basic Prevention in high blood pressure (HAPPHY), Metoprolol Atherosclerosis Prevention in Hypertensives (MAPHY), and therapy of gentle high blood pressure learn (TOMHS)-contrasting diuretics, -adrenergic receptor blockers, angiotensin changing enzyme inhibitors, -adrenergic receptor blockers, and calcium antagonists ·considers cures and effects with older hypertensives ·and extra! experiences at the collaboration among the area healthiness association and the foreign Society of high blood pressure pooling facts from greater than 30 scientific trials at present in growth. Written through over ninety specialists and containing greater than 1500 references, drawings, tables, and equations, scientific Trials in high blood pressure satisfies the reference wishes of cardiologists and cardiovascular experts, nephrologists, geriatricians, endocrinologists, internists, relatives perform physicians, pharmaceutical scientists, and graduate and clinical university scholars in those disciplines.
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Extra info for Clinical Trials in Hypertension
United States Public Health Service Cooperative Studies Group. Morbidity and mortality in mild essential hypertension. Circ Res (suppl II) 1972; 30, 31:110–124. 16. Armitage P. Sequential Medical Trials. Springfield, IL: Charles C Thomas, 1960. 17. Mild Hypertension: to treat or not to treat. Perry HM Jr, Smith WM, eds. Vol. 304. Ann NY Acad Sci, 1978. This Page Intentionally Left Blank 3 The Hypertension Detection and Follow-Up Program BARRY R. DAVIS and CHARLES E. FORD The University of Texas–Houston School of Public Health, Houston, Texas I.
4. 5. Could hypertensives in an entire community be identified, brought under modern pharmacologic management, and kept under such management? Would intervention of hypertension identified in the population of the community at large reduce the occurrence of associated disease and death? Would therapeutic efficacy exceed toxicity in the mild hypertensive and justify long-term treatment? Would pharmacologic control of elevated BP be effective in young adults and women? Would the occurrence of myocardial infarction and coronary death be decreased by antihypertensive therapy?
Leishman AWD. Merits of reducing high blood pressure. Lancet 1963; 1:1284. 7. Bjork S, Sannerstedt R, Falkheden T, Hood B. Effect of active drug treatment in severe hypertensive disease. Acta Med Scand 1961; 169:673. 8. Veterans Administration Cooperative Study Group on Antihypertensive Agents. Effects of treatment on morbidity in hypertension. JAMA 1967; 202:1028–1034. 9. Smith WM, Damato AN, Galluzzi NJ, Garfield CF, Hanowell EG, Stimson WH, Thurm RH, Walsh JJ, Bromer L. Evaluation of antihypertensive therapy-cooperative clinical trial method: I.