By Catherine Haberland MD
This full-color textual content and atlas, offers a whole assessment of the structural changes of significant worried process ailments, in addition to their scientific manifestations. Readers will comprehend the objectives of the neuropathologic examination, the histologic response of neural tissue to illnesses, and the pathologic stipulations specific to the anxious procedure. All themes are highlighted via gross and histologic pictures of the mind and spinal wire, and all combine the newest medical stories.
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Cerebellar tonsillar herniation, or pressure cone syndrome, manifests with rising systolic and diastolic blood pressure, bradycardia, and irregular breathing, culminating in respiratory arrest. Brainstem hemorrhage is a terminal event manifested by coma, small nonreactive pupils, bilateral pyramidal signs, and decerebrate posturing. 8). Hydrocephalus is classified as obstructive, nonobstructive, and other. Obstructive Hydrocephalus Obstructive hydrocephalus is the most common type. Obstruction to CSF circulation may occur within the ventricles or within the subarachnoid space.
B. Extravasated plasma infi ltrates the white matter and the pericapillary spaces. C. The white matter is vacuolated and spongy, and the myelin sheaths are separated from each other and are broken up (LFBCV). D. Hypertrophied GFAP-positive astrocytes are noted in spaces between the myelin sheaths (immunostains). A B C D Histologically, the edematous white matter stains pale with Luxol fast blue, except for the arcuate fibers, which are relatively well preserved. Lakes of sera fi ll the pericapillary spaces (Fig.
Frequent, incidental age-related fi ndings are periventricular caps and rims corresponding to periventricular ischemic demyelination (Fig. 22). 23 Cerebral artifacts. “Swiss cheese” brain showing A. multiple smooth-walled cavities, B. corresponding to empty holes lacking tissue reaction (HE). Artificial histologic changes. C. Dissolution of granule cells in cerebellar cortex. D. Spiky neurons in surgical specimen (HE). A C The pathomechanism of cerebral aging is complex. Mitochondria play a central role in the aging process.