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By Dismukes W.E., Pappas P.G., Sobel J.D.

Univ. of Alabama, Birmingham. bargains a accomplished overview of this self-discipline and covers microbiologic, epidemiologic, and demographic facets of fungal infections, in addition to diagnostic, scientific, healing, and preventive methods. additionally covers numerous new antifungal medicinal drugs and addresses distinctive sufferer populations. DNLM: Mycoses — etiology.

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Detection of amphotericin B-resistant Candida isolates in a brothbased system. Antimicrob Agents Chemother 39: 906–909, 1995. Rex J H, Pfaller M A, Galgiani J N, Bartlett M S, Espinel-Ingroff A, Ghannoum M A, Lancaster M, Odds F C, Rinaldi M G, Walsh T J, Barry A L. Development of interpretive breakpoints for antifungal susceptibility testing: conceptual framework and analysis of in vitro—in vivo correlation data for fluconazole, itraconazole, and Candida infections. Clin Infect Dis 24: 235–247, 1997.

Pappagiannis D, Zimmer B L. Serology of coccidioidomycosis. Clin Microbiol Rev 3: 247–268, 1990. Perfect J R, Cox G M. Drug resistance in Cryptococcus neoformans. Drug Resist Updates 2: 259–269, 1999. Perfect J R, Cox G M, Lee J Y, Kauffman C A, deRepetigny L, Chapman S W, Morrison V A, Pappas P, Hiemenz J W, Stevens D A. The impact of culture isolation of Aspergillus species: a hospitalbased survey of aspergillosis. Clin Infect Dis 33: 1924–1833, 2001. Peyron F, Favel A, Michel-Nguyen A, Gilly M, Regli P, Bolmstrom A.

Both isolates were unresponsive to amphotericin B in a murine model of invasive aspergillosis, but only the A. terreus isolate tested resistant in vitro. A wide range of media and test conditions failed to distinguish the resistant A. fumigatus isolate from two isolates that were susceptible in vivo. In contrast, using a straightforward adaptation of the M27 procedure, Lass-Florl and coworkers demonstrated a good correlation between amphotericin B MICs of Ն 2 ␮g/ml and an increased likelihood of clinical failure in patients with aspergillosis (Lass-Florl et al, 1998).

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