By A.T. Sumner, A.C. Chandley
When the past due Professor C. D. Darlington based what built into the foreign Chromosome meetings in Oxford in 1964, he used to be involved that scientists who labored on assorted facets of chromosomes, or who studied them in numerous methods, must have the potential of "discussing the elemental difficulties of chromosomes with one another". the truth that good over three hundred scientists with a large choice of pursuits got here to Edinburgh in August 1992 for the eleventh overseas Chromosome convention exhibits that there's nonetheless an identical want, and in addition the need between chromosomologists to have such discussions. the current quantity includes just about all the invited contributions, and attests to the variety of methods and functions in chromosomal reports. many years in the past it might have looked as if it would a few that chromosome reviews have been being outmoded via molecular biology, however the molecular biologists have now discovered that they should find out about chromosomes, and certainly a big, if ill-defined self-discipline of 'molecular cytogenetics' has grown up in recent times. we're happy that during making plans the convention and this publication, loads of the paintings awarded is on the interface among cytogenetics and molecular biology. this would definitely proceed sooner or later, as obstacles among disciplines are mostly man made, and every has a lot to benefit from the others.
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Extra info for Chromosomes Today: Volume 11
1986) EM investigations of surface spread synaptonemal complexes in a human male carrier of a pericentric inversion inv(13)(pI2qI4): the role of heterosynapsis for spermatocyte survival. Ann. Hum. , et al(1988) Primer-directed enzymatic am plication of DNA with a thermostable DNA polymerase. Science, 239, 487-491 Seabright, M. (1971) A rapid banding technique for human chromosomes. E. (1942) Sex chromosomes in a human intersex. Amer. H. et al (1990) A gene from the human sex determining region encodes a protein with homology to a conserved DNA-binding motif.
In this way, five additional clones were selected (Figure 1) and their DNA sequences determined. A 3113 bp contiguous sequence corresponding to the CENP-C message was constructed from these overlapping cDNAs. This sequence possesses a single long open reading frame, which begins 158 bp from the 5' end and extends for 2829 bp, encoding a protein of deduced molecular weight 107 kDa (Figure 3). We used two criteria to determine that the AUG codon 158 bp from the 5' end of the sequence is likely to be the bona fide translational initiation codon for CENP-C.
6 References Arnold, T. (1879) Beobachtungen uber Kentheilungen in den Zellen der Geschwulste. Virchows Arch. et al(1991) X- chromosome inactivation may explain the difference in viability of XO humans and mice. L. G. (1949) A morphological distinction between neurones of the male and female, and the behaviour of the nucleolar satellites during accelerated nucleo-protein synthesis. , Wiegant, I. and van Duijn, P. (1983) The development, using poly (Hg-U) in a model system, of a new method to visualise hybridisation in fluorescence microscopy.