By Jens Moeller
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Additional info for Cholesterol: Interactions with Testosterone and Cortisol in Cardiovascular Diseases
Our aim is to counteract the process with testosterone. 36 Negative Nitrogen Balance Excess of Cortisol "Normally (this) breakdown of protein is counterbalanced by anabolic processes but excess of cortisol causes a negative nitrogen balance .... Cortisol excess raises blood lipids and the plasma cholesterol level. This leads to arteriosclerosis" (Keele and Neil 1982. Emphasis added). This textbook confirms that excess of cortisol leads to a negative nitrogen balance and hence to CVD. The underlying biochemical processes are as follows: cortisol breaks down protein to amino acids from which glycogen is formed by the activation of the appropriate enzymes.
What would such a patient think and feel about doctors who allowed his disastrous condition to remain untreated and so ruined his life? Initially, I treat my so-called "maturity-onset diabetic" patients with relatively high doses of testosterone to gain an immediate effect. The dosage is reduced gradually and I usually end up by giving testosterone depot 250 mg once a month. It is accepted in medical centers that maturity-onset diabetes is often found in patients with CVD - but it is especially pointed out that ketone bodies are rarely found.
Evaluation of the Parameters of CVD Despite the superior results obtained by hormone treatment for deteriorated circulation, we face difficulties in accommodating them to the narrow statistics of clinical trials. Describing the situation in my clinic is worth many such trials. Many patients are sent by their own doctors because of their deteriorated circulation. They consult me primarily about limb pain and restlessness at night that keeps them from sleeping. I am able to help the majority of these patients by hormone treatment.