Download Cell Cycle and Cell Differentiation by S. R. Dienstman, H. Holtzer (auth.), J. Reinert, Howard PDF

By S. R. Dienstman, H. Holtzer (auth.), J. Reinert, Howard Holtzer (eds.)

It is instructive to match the reaction of biologists to the 2 subject matters that contain the identify of this quantity. the idea that of the mobile cycle-in contra­ contrast to mobilephone division-is a comparatively fresh one. however biologists of all persuasions get pleasure from and with no trouble agree at the relevant difficulties during this quarter. concerns starting from mechanisms that begin and combine the synthesis of chro­ mosomal proteins and DNA in the course of S-phase of mitosis to the way during which meeting of microtubules and their interactions result in the segregation of metaphase chromosomes are simply by means of botanists and zoologists, in addition to by means of phone and molecular biologists. those difficulties are crisp and well-defined. the present country of "cell differentiation" stands in sharp distinction. This, one of many oldest difficulties in experimental biology, virtually defies definition this day. The problems come up not just from an absence of pertinent details at the regulatory mechanisms, but in addition from conflicting uncomplicated recommendations during this box. one of many ways that this case will be more advantageous will be to discover a broader experimental foundation, together with a greater figuring out of the connection among the mobilephone cycle and mobile differentiation.

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Inhibition of cartilage development by BUdR. Develop. Bioi. 28, 430 (1972). : The globins of adult and embryonic chick l-Ib. Biochim. Biophys. Acta 127, 59 (1966). : Synthesis of globin RNA from duck reticulocyte chromatin in vitro. Proc. Natl. Acad. Sci. USA 70, 2029 (1973). : The structure of chromatin as revealed by DNase digestion studies. Biochim. Biophys. Acta 281, 453 (1972). : Inhibition of myoblast fusion after one round of DNA synthesis in BUdR. J. Cell Bioi. 44, 134 (1970). : Genetic regulation in higher cells.

Acad. Sci. 70, 2096 (1973). WILT, F. : Regulation of the initiation of chick embryo Hb synthesis. J. Mol. Bioi. 12, 331 (1965). HUNT Institute of Neurological Sciences, University of Pennsylvania School of Medicine, Philadelphia, PA, USA I. Introduction The first principle of neuronal differentiation is the generation of cellular diversity which, at least quantitatively, matches that found in the entire remainder of the embryo. More importantly, it is the characteristic differences among neurons (rather than properties which all neurons share to the exclusion of nonneural cells) that enables them to associate selectively and to assemble the synaptic circuits which are the substrates of macroscopic brain function.

37, 599--{)05 (1973). 22 S. R. DIENSTMAN and H. : Developmental processes in higher vertebrates. London: Logos Press 1971. : The effect of mitotic inhibitors on myogenesis. J. Cell Bioi. 36, 111-128 (1968). : Mitosis and the processes of differentiation of myogenic cells in vitro. J. Cell Bioi. 41, 188 (1969). : Inhibition of myoblast fusion after one round of DNA synthesis in 5-bromodeoxyuridine. J. Cell Bioi. 44, 134-150 (1970). : Cytoplasmic actin: A comparative study. Cold Spring Harbor. Symp.

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