Download Cardiotoxicity of Non-Cardiovascular Drugs by Giorgio Minotti PDF

By Giorgio Minotti

Content material:
Chapter 1 Mitochondrial disorder in mobilephone harm and Cardiotoxicity (pages 1–23): Fabio Di Lisa, Martina Semenzato, Andrea Carpi, Sara Menazza, Nina Kaludercic, Roberta Menabo and Marcella Canton
Chapter 2 Cardiovascular Liabilities of gear: Regulatory facets (pages 25–45): Claudio Arrigoni
Chapter three mobile Mechanisms, Molecular pursuits, and Structure–Function Relationships in Drug?Induced Arrhythmias: Antihistamines, Psychoactive medications, and Antimicrobial brokers (pages 47–96): Maria Virginia Soldovieri and Maurizio Taglialatela
Chapter four Cardiovascular Toxicity of Antitumor medicines: Dimensions of the matter in childrens (pages 97–126): Rebecca Scully and Steven E. Lipshultz
Chapter five Cardiovascular Toxicity of Antitumor medicines: measurement of the matter in grownup Settings (pages 127–199): Joseph R. Carver and Chaitali J. Desai
Chapter 6 Diagnostic features of Cardiovascular Toxicity of Antitumor medicinal drugs (pages 201–221): Michael S. Ewer and Thomas M. Suter
Chapter 7 Cardiovascular Toxicity of Antitumor medicines: Translating Molecular Mechanisms into scientific proof (pages 223–256): Pierantonio Menna, Emanuela Salvatorelli, Carlo Salsano, Luca Gianni and Giorgio Minotti
Chapter eight NSAID motion and the principles for Cardiovascular Toxicity (pages 257–285): Anna L. Blobaum and Lawrence J. Marnett
Chapter nine Cardiovascular Toxicities of NSAIDS: Epidemiologic features (pages 287–312): Antonio Gonzalez?Perez and Luis Alberto Garcia Rodriguez
Chapter 10 Cardiovascular Toxicities of Life?Saving medicinal drugs: Antiviral treatment (pages 313–332): James J. Kohler and William Lewis

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11. G. H. Orchard, Myocardial contractile function during ischemia and hypoxia, Circ. , 60, 153–168 (1987). 12. A. W. R. Neely, Coenzyme A and carnitine distribution in normal and ischemic hearts, J. Biol. , 253(12), 4310–8 (1978). 13. M. C. Messineo, Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardium, Circ. , 48, 1–16 (1981). 14. B. W. E. Sobel, Amphipathic metabolites and membrane dysfunction in ischemic myocardium, Circ. , 55, 135–154 (1984). 15. E. R. Pfeiffer, Mechanisms by which mitochondria transport calcium, Am.

Ppt]. 4 SUMMARY Cardiovascular adverse effects of drugs can be divided into two categories: pharmacological and toxicological. Pharmacological adverse effects usually appear after a single drug administration, are due to interference with receptors and/or ion channels and are investigated by means of safety pharmacology studies. Toxicological adverse effects usually appear following repeated administrations of the drug (from weeks to months or even years), can be caused by a variety of mechanisms (including a direct cytotoxic effect) and are investigated during classical repeated-dose toxicology studies.

Hypertension is an uncommon sideeffect of drugs, but some medications are recognized to induce it: among these are erythropoietin, ciclosporin, corticosteroids, NSAIDs, COX-2 inhibitors [2] and, most recently, kinase inhibitors developed for the treatment of cancer [5,6]. Delayed ventricular repolarization is a more common side-effect of drugs, and some have been removed from the market for this (cisapride, terfenadine, astemizole, among others) [7–9]. The best known example of a toxicological adverse event is the congestive heart failure induced by anthracyclines, which was first reported in 1967 [10].

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