By Alessandra Pagliarani; Fabiana Trombetti; Vittoria Ventrella
Organotins are common contaminants specifically of water environments. Their chemically flexible constitution makes organotin compounds capable of bind to numerous biomolecules therefore broadly affecting organic capabilities. Trisubstituted molecules, specifically tributyltin (TBT) and triphenyltin (TPhT), were largely hired in antifouling paints and also are exploited as plastic stabilizers that regrettably reason destructive organic results. continual bioaccumulation has ended in organotins changing into an important environmental hazard. bankruptcy by means of bankruptcy, the organic and biochemical effec. Read more... 01 name Page.pdf; 02 name web page; 03 REVISED eBooks finish consumer License Agreement-Website; 04 Prof Nagy memorial; 05 Contents _Index_; 06 Foreword; 07 Preface; 08 checklist of individuals; 09 ABBREVIATION checklist OF ORGANOTINS; 10 bankruptcy 1 ready_KW_; eleven bankruptcy 2 ready_KW_ revised; 12 bankruptcy three prepared KW; thirteen bankruptcy four ready_KW_; 14 bankruptcy five ready_KW_; 15 bankruptcy 6 ready_KW_revised; sixteen bankruptcy 7 ready_KW_; 17 bankruptcy eight ready_KW_ revised; 18 bankruptcy nine ready_KW_; 19 bankruptcy 10 prepared _KW_ revised; 20 bankruptcy eleven ready_KW_; 21 bankruptcy 12 prepared _KW_; 22 Index
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Extra info for Biochemical and Biological Effects of Organotins
The main chemical features of the two compounds were also previously published . These complexes are moderately water-soluble and very slowly hydrolyze towards the corresponding tin hydroxides or oxides. Both complexes exhibited strong antitumor activities on several human tumor cell lines, even stronger that those induced by some classical antitumor drugs. Biological Activity of Organotin(IV) Compounds Biochemical and Biological Effects of Organotins 31 IC50 values were found in 1-5 nM range for compound I and in the 50-200 nM range for compound II were found .
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Bryan GW, Bright DA, Hummerstone LG, et al. Uptake, tissue distribution and metabolism of 14C-labelled tributyltin (TBT) in the dog-whelk, Nucella lapillus. J Mar Biol Assoc UK 1993; 73: 889-912. Lee RF. Metabolism of tributyltin oxide by crab, oyster and fish. Mar Environ Res 1985; 17: 145-148. Matsuda R, Suzuki T, Saito Y. Metabolism of tri-n-butyltin chloride in male rats. J Agric Food Chem 1993; 41: 489-95. Horiguchi T. Imposex caused by organotin compounds in marine gastropods from Japan [PhD Thesis, in Japanese].