By Saul Suster
The mediastinum is a digital compartment within the chest hollow space that's the seat of numerous very important organs and buildings that may be thinking about quite a few pathologic approaches, together with congenital and developmental abnormalities, inflammatory stipulations, and benign and malignant neoplasms. The Atlas of Mediastinal Pathology presents a pictorial survey of the key ailment approaches that may have an effect on this anatomic compartment, together with congenital and purchased cysts, benign hamartomatous techniques, inflammatory procedures regarding the mediastinum, and benign and malignant neoplasms. The latter contains tumors of the thymus (thymoma and thymic carcinoma), neuroendocrine neoplasms, germ phone tumors, mesenchymal neoplasms, and hematolymphoid malignancies. using ancillary diagnostic equipment is illustrated, the place acceptable, delivering guidance for pathologists in arriving on the right diagnosis.
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Additional resources for Atlas of Mediastinal Pathology
The tumor cells in this case were p63 positive and negative for neuroendocrine markers Fig. 31 Ribbon-like growth pattern in spindle-cell thymoma shows a lobulated growth surrounded by connective tissue that contains serpiginous cords of tumor cells; the pattern can be highly reminiscent of a neuroendocrine neoplasm such as thymic carcinoid 28 Fig. 32 Higher magnification from ribbon-like growth pattern in spindle-cell thymoma shows spindle to oval cells with hyperchromatic nuclei aligned in parallel arrays forming serpiginous cords of cells Fig.
Instead, the small empty vacuoles contain a single small lymphocyte Fig. 61 An unusual histologic appearance that can sometimes be observed in lymphocyte-rich thymomas (WHO type B1) constitutes areas that closely resemble the normal thymic medulla (including the presence of Hassall’s corpuscles) admixed with areas that recapitulate the normal cortex. 4 Fig. 62 Higher magnification of “organoid” thymoma shows a small, well-formed Hassall’s corpuscle in a medullary-like area surrounded by a lymphocyte-rich population.
3 Fig. 50 Lymphocyte-rich spindle-cell thymoma (WHO type AB) can sometimes be exclusively composed of sheets of lymphocytes admixed with small spindly epithelial cells without more overt lymphocyte-poor spindle-cell areas. These tumors can be easily mistaken for the WHO B1 type of thymoma Fig. 51 Higher magnification of the preceding field in WHO type AB thymoma shows the proliferating epithelial cells to be of spindlecell type, with oval nuclei showing dispersed chromatin and absent or inconspicuous nucleoli and no discernible cytoplasm.