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By Walter Hendelman M.D.

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Large-scale randomized trials could provide positive results to justify the rational use of certain antioxidants, and null results could limit the unneeded use of supplements and allow for a focus on proven therapies. S. 27 Antioxidant use in the general population was increasing at that time, and researchers realized that randomized trials would have to start soon so that enough people would be willing to be assigned to a placebo group. In this chapter, we review the large-scale clinical trials of vitamin E alone, beta-carotene alone, vitamin C, and combination antioxidants in both the primary and secondary prevention of CVD.

Evaluation of the benefits and risks of antioxidants is essential for determining the place of these supplements in clinical medicine. Large-scale randomized trials could provide positive results to justify the rational use of certain antioxidants, and null results could limit the unneeded use of supplements and allow for a focus on proven therapies. S. 27 Antioxidant use in the general population was increasing at that time, and researchers realized that randomized trials would have to start soon so that enough people would be willing to be assigned to a placebo group.

Dietary flavenoids reduce lipid peroxidation in rats fed polyunsaturated or monounsaturated fat diets. J Nutr 1998;128:1495–1502. 12. Ancel K. Coronary heart disease in seven countries. New York: American Heart Association Monograph Number 29. 1970. 13. Knoops KTB, de Groot LCPGM, Kromhout D, Perrin A-E, Moreisas-Varela, Menotti A, van Staveren WA. Mediterennanean diet, lifestyle factors, and 10 year mortality in elderly European men and women. JAMA 2004;292:1433–1439. 14. Kratz M, Cullen P, Kassner F, Fobker M, Abuja PM, Assmann G, Wahrburg U.

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