By National Research Council, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels
This booklet is the 6th quantity within the sequence Acute publicity instruction degrees for Selected Airborne Chemicals, and contains AEGLs for chemical substances akin to ammonia, nickel carbonyl and phosphine, between others.
At the request of the dept of safety, the nationwide examine Council has reviewed the suitable clinical literature compiled via a professional panel and validated Acute publicity guide degrees (AEGLs) for 12 new chemical compounds. AEGLs characterize publicity degrees less than which antagonistic overall healthiness results aren't more likely to ensue and are beneficial in responding to emergencies reminiscent of unintended or intentional chemical releases in the neighborhood, the office, transportation, the army, and for the remediation of infected sites.
Three AEGLs are authorized for every chemical, representing publicity degrees that lead to: 1) striking yet reversible pain; 2) long-lasting health and wellbeing results; and three) life-threatening wellbeing and fitness impacts.
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Extra info for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6
The two surviving rabbits had labored breathing and decreased activity as well as edema and hair loss directly below the area of the test article application. All three rabbits had skin corrosion (necrosis) immediately after the 3-min exposure, and eschar formation was evident from 24 h through the 7-day observation period. Hine et al. 76 g/mL). No deaths resulted from the application of 13 or 25 mg/kg of allylamine (observation period unclear, perhaps several weeks); 3/3 rabbits died 3-24 h after treatment with 50 mg allylamine/kg, and 3/3 died 3-4 h after application of 100 mg.
5 ppm, which was the lowest effect level. The MF was used because exposure was for only 5 min and it is unclear whether “moderate” irritation or discomfort is comparable to “notable” irritation or discomfort, which exceeds the scope of AEGL-1. An intraspecies uncertainty factor of Copyright © National Academy of Sciences. All rights reserved. Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6 37 Allylamine 3 was applied because allylamine acts as a contact irritant, and the severity of its effects is not expected to vary greatly among humans.
The most common heart lesions were interstitial fibrosis with areas of necrosis, muscle bundle polymorphonuclear cell infiltration, and inflammation of the smaller blood vessels. This study is summarized with all other multiple-exposure inhalation animal studies (described in the following sections) in Table 1-6. In an experiment to evaluate the effect of inhaled allylamine on EKGs, young adult Fischer 344 rats (5/sex) were exposed to 100 or 150 ppm for 6 h/day for 10 days over a 3-week-period (Lynch et al.