By National Research Council, Division on Engineering and Physical Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels
Tremendous unsafe components (EHSs)² could be published unintentionally because of chemical spills, commercial explosions, fires, or injuries related to railroad vehicles and vans transporting EHSs. employees and citizens in groups surrounding commercial amenities the place EHSs are synthetic, used, or saved and in groups alongside the nation's railways and highways are probably prone to being uncovered to airborne EHSs in the course of unintended releases or intentional releases through terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental safety employer (EPA) has pointed out nearly four hundred EHSs at the foundation of acute lethality information in rodents. As a part of its efforts to boost acute publicity instruction degrees for EHSs, EPA and the corporation for poisonous components and illness Registry (ATSDR) in 1991 asked that the nationwide study Council (NRC) advance instructions for constructing such degrees. in accordance with that request, the NRC released directions for constructing group Emergency publicity degrees for dangerous components in 1993. thus, common working techniques for constructing Acute publicity instruction degrees for harmful components used to be released in 2001, supplying up-to-date tactics, methodologies, and different guidance utilized by the nationwide Advisory Committee (NAC) on Acute publicity instruction degrees for dangerous ingredients and the Committee on Acute publicity guide degrees (AEGLs) in constructing the AEGL values. In 1998, EPA and DOD asked that the NRC independently evaluate the AEGLs built by means of NAC. according to that request, the NRC equipped inside its Committee on Toxicology (COT) the Committee on Acute publicity guide degrees, which ready this file. Acute publicity instruction degrees for chosen Airborne chemical substances is the 10th quantity of the sequence and records for N,N-dimethylformamide, jet propellant fuels five and eight, methyl ethyl ketone, perchloromethyl mercaptan, phosphorus oxychloride, phosphorus trichloride, and sulfuryl chloride.
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Extra info for Acute Exposure Guideline Levels for Selected Airborne Chemicals
In an additional study by Lundberg et al. (1986), groups of six rats inhaled air only or DMF for 4 h at approximate concentrations of 140, 280, 560, 1,120, or 2,250 ppm (420, 840, 1,680, 3,360, and 6,720 mg/m3, respectively; reported as 1/32, 1/16, 1/8, 1/4, or 1/2 of the saturation concentration). Hepatic damage was assessed 20 h later by measuring serum sorbitol dehydrogenase (SDH) in all rats and by histologic analysis of liver from rats exposed at 2,250 ppm (6,720 mg/m3). 05) in rats exposed at 280 or 560 ppm (1/16 or 1/8 of the saturation concentration; exact SDH values not provided) compared with controls, the greatest increase occurring in rats exposed at 560 ppm.
High-dose female rats had an increased length of estrous cycle compared with controls. No definitive exposure-related effects were observed in renal function, blood pressure, or electrocardiogram readings or in male reproductive parameters.
Facial flushing following ethanol consumption was noted by 70% of the DMF-exposed workers compared with 4% of unexposed controls. Exposed workers had significant increases in GGT and ALT activities. 7 ppm) to DMF, and alcohol consumption was assigned using the criteria of consuming no alcohol, consuming <50 g/day, or consuming >50 g/day. A ranking sum value based on GGT, AST, and ALT levels was determined for all groups. The results demonstrated that chronic occupational DMF exposure can impair liver function, and drinking alcohol was synergistic with the hepatotoxicity of DMF.